Centre for Membrane Pumps in Cells and Disease - PUMPkin


The Centre for Membrane Pumps in Cells and Disease - PUMPkin is a Centre of Excellence funded by the Danish National Research Foundation.

PUMPkin research investigates the structure and mechanism of membrane proteins of the P-type family, such as the sodium pump, proton pump, calcium pump, heavy metal pumps and lipid flippases, as well as (patho)physiological aspects of their function, and their potential as drug targets in human disease and pathogens.


2015.09.10 | Awards

PUMPkin director Poul Nissen awarded the international Gregori Aminoff Prize 2016

The Royal Swedish Academy of Sciences has decided to award the Gregori Aminoff Prize in crystallography 2016 to Professor Poul Nissen, Aarhus University, Denmark, and Professor Chakashi Toyoshima, University of Tokyo, Japan. The Aminoff Prize is one of the Academy’s few international awards, and former prize winners include several Nobel laureates.

2015.09.07 | Knowledge exchange

Surprise: Plant roots eat lipids

As a complete surprise, new results show that plants can take up lipids from the soil through their roots. The research, which is published in the scientific journal Nature Communications, is lead by researchers affiliated PUMPkin and Dept. Plant and Environmental Sciences at the University of Copenhagen.

2015.02.05 | Research news

Ion pumps in cells and their importance for nervous disorders

More knowledge about cellular ion pumps will pave the way for improved treatment of neurological disorders. Molecular Biologist Hanne Poulsen has just been awarded a Lundbeck Foundation Fellowship valued at DKK 10 million for a five-year research project.

2015.01.28 | Research news

New steroid-bound structures of the sodium-potassium pump broaden our knowledge about this enzyme

Na+,K+-ATPase is the ion pump responsible for maintenance of the electrochemical gradients of Na+ and K+ across the membrane of animal cells. Cardiotonic steroids constitute a broad class of specific Na+,K+-ATPase inhibitors, including drugs of clinical importance with multiple physiological effects. The existence of several endogenous cardiotonic…

2014.10.30 | Research news

New knowledge about neurotransmitter pathways in the brain

Insight into transport mechanisms in brain cells is extremely important in connection with disorders such as schizophrenia, epilepsy and depression, as well as in connection with producing the right medicine. Defects in proteins responsible for the transport of neurotransmitters are actually related to psychological and neurological disorders, and…

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Highlights 2011 from the PUMPkin Centre

Read about the scientific highlights during 2011, including a few words on our midterm evaluation.