Researchers identify mechanism of a known toxic compound in food

The toxic compound cyclopiazonic acid (CPA) has been known for many years, but it is only now that researchers have found out how the toxic compound works. This discovery will help researchers to develop new antibiotics.

2009.09.23 | Karen Bech

The CPA toxin (purple) sits right at the edge of the membrane and prevents the calcium ions (the light blue balls) from being transported to the other side of the membrane. Under the stop sign you see the toxin CPA (purple) which acts as a plug in the calcium pump.

Published article:
Mette Laursen et al. (2009) Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. Journal of Biological Chemistry, 284, p. 13513-18, May 15
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